This retrospective analysis, conducted at the Stanford PANS clinic, examines the impact of nonsteroidal anti-inflammatory medications on neuropsychiatric symptoms in PANS/PANDAS patients. The authors review the records of 218 patients. Their findings suggest that NSAIDs may be helpful for treating neuropsychiatric symptoms in some patients. The authors also provide a detailed description of the clinical course of three patients who had dramatic improvements in their neuropsychiatric symptoms corresponding with NSAID introduction, and clear deteriorations upon removal. ¹

This article investigates the effectiveness of corticosteroids in patients treated at the Stanford PANS clinic for new-onset and relapsing/remitting PANS/PANDAS. The authors report that when given early in a flare, corticosteroids can more quickly improve symptoms and allow patients to achieve remission of symptoms more readily. Furthermore, longer courses of corticosteroids may result in lengthier, more durable periods of remission. ²